Cel New neurons are continuously generated in certain regions of adult mammalian brain. One of those regions is the dentate gyrus, a subregion of hippocampus, which is essential for memory formation. Although these new neurons in the adult dentate gyrus are thought to have an important role in learning and memory, it is largely unclear how new neurons are involved in information processing and storage underlying memory. Because new neurons constitute a minor portion of intermingled local neuronal population, simple application of conventional techniques such as multi-unit extracellular recording and pharmacological lesion are not suitable for the functional analysis of new neurons. In this proposed research program, I will combine multi-unit recording and behavioral analysis with virus mediated, cell-type-specific genetic manipulation of neuronal activity, to investigate computational roles of new neurons in learning and memory. Specifically, I will determine: 1) specific memory processes that require new neurons, 2) dynamic patterns of activity that new neurons express during memory-related behavior, 3) influence of new neurons on their downstream structure. Further, based on the information obtained by these three lines of studies, we will establish causal relationship between specific memory-related behavior and specific pattern of activity in new neurons. Solving these issues will cooperatively provide important insight into the understanding of computational roles performed by adult neurogenesis. The information on the function of new neurons in normal brain could contribute to future development of efficient therapeutic strategy for a variety of brain disorders. Dziedzina nauki natural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologygenetic engineeringnatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysisnatural sciencescomputer and information sciencesdata sciencedata processing Słowa kluczowe adult neurogenesis hippocampus Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS4 - ERC Starting Grant - Physiology, Pathophysiology and Endocrinology Zaproszenie do składania wniosków ERC-2007-StG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Wkład UE € 1 673 743,00 Adres HOGSKOLERINGEN 1 7491 Trondheim Norwegia Zobacz na mapie Region Norge Trøndelag Trøndelag Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stig Slordahl (Prof.) Kierownik naukowy Ayumu Tashiro (Ph.D.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Norwegia Wkład UE € 1 673 743,00 Adres HOGSKOLERINGEN 1 7491 Trondheim Zobacz na mapie Region Norge Trøndelag Trøndelag Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stig Slordahl (Prof.) Kierownik naukowy Ayumu Tashiro (Ph.D.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych NANYANG TECHNOLOGICAL UNIVERSITY Singapur Wkład UE € 318 000,00 Adres NANYANG AVENUE 50 639798 Singapore Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Mei Fong Loong (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
