Objective
According to the World Health Organization (WHO), 1.6 billion adults are overweight and 300 million people are obese worldwide. One of the major consequences of these high rates is manifested by the increased prevalence of Type II Diabetes Mellitus (T2D). The search for novel therapies requires a better understanding of the T2D pathophysiology. In this regard, there is still a considerable lack of knowledge concerning the immunopathogenesis of T2D. We discovered a natural phytohormone -- abscisic acid (ABA) -- with significant glucose normalizing and immunomodulatory properties, which may prove instrumental in exploring the links between immunity and T2D. Our preliminary data suggest that ABA ameliorates glucose tolerance and white adipose tissue (WAT) inflammation by acting on peroxisome proliferator-activated receptor γ (PPAR γ). Our long-term goal is to characterize the mechanisms by which ABA ameliorates obesity-related inflammation. Specific aim 1 will test the hypothesis that ABA down-modulates monocyte chemoattractant protein-1 (MCP-1) production through a PPAR γ-mediated blockade of nuclear factor-κB (NF-κB). More specifically, we will dissect the mechanisms of transcriptional regulation of MCP-1 expression by ABA by: 1) Determining the influence of ABA treatment on the DNA-binding activity of NF-κB in macrophages; 2) Investigating whether ABA represses the expression of NF-κB subunits or induces IκBα expression under inflammatory conditions, 3) Assessing the physical interaction of ABA-activated PPAR γ and RelA and its role in inhibiting MCP-1 expression in macrophages; and 4) Determining if ABA suppresses obesity-induced MCP-1 expression by activating PPAR γ and inhibiting NF-κB. Specific Aim 2 will evaluate the differential ability of ABA’s enantiomers and isomers to bind and activate PPAR γ in vitro and determine whether macrophage PPAR γ is required for ABA’s induced improvement of insulin resistance during diet-induced obesity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08500 Vic Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.