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Content archived on 2024-06-18

Early and late health risks to normal/healthy tissues from the use of existing and emerging techniques for radiation therapy

Objective

Curative cancer treatment with radiation seeks to optimise the magnitude of the radiation dose to the treatment volume while restricting the dose to normal healthy tissue. With an increasing population of surviving cancer patients treated with radiation therapy, the harmful effects of the radiation to normal tissue are becoming more evident. The ALLEGRO project will address the many aspects of normal healthy tissue damage that are not yet well understood in both conventional treatment techniques and emerging techniques (protons, heavy ions). The project will include measurement of radiation doses outside the treatment volume and investigation of the accuracy of methods of dose calculation in this region. The extensive existing databases of radiation treatments and outcomes will be used to investigate models of normal tissue damage and second primary cancer. The measurements and data analysis will be supported by theoretical modelling and surveys to develop the link between radiobiological mechanisms and empirical normal tissue complication (NTCP) models, and to extend conventional models to apply to the emerging techniques. The project is restricted to two years, so there will be a limit to the amount of new research possible. Therefore an essential part of the project will be to engage a forum of experts to redefine the current knowledge on normal tissue damage following radiotherapy, identify gaps in the knowledge and make recommendations for future research, data collection, and technological developments. The final report will consist of a series of focused documents directed to clinicians (for the application of normal tissue risks in treatment optimisation), equipment manufacturers (recommendations on safety design), and the research community (summary of knowledge and recommendations on data collection and project proposals).

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-Fission-2008
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI PAVIA
EU contribution
€ 478 440,00
Address
STRADA NUOVA 65
27100 Pavia
Italy

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Region
Nord-Ovest Lombardia Pavia
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (12)

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