Objective
We propose a multidisciplinary “translational research” project that will exploit the molecular and cellular features of innate immunity potentially involved in the pathogenesis of autoimmune diseases in humans. Given the significant scientific advances over the past years in characterizing the physiology of cells from the innate immune system, we will attempt to identify the role of natural killer (NK) cells and dendritic cells (DCs) in the physiopathology of various autoimmune disorders. Combining different professional expertise in clinical and basic immunology, we plan the following: 1) To select cohorts of patients affected by several systemic autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (scleroderma) and other various forms of vasculitis. We will conduct our investigations on both naive untreated patients with active disease and patients undergoing immuno-suppressive therapy with disease in remission, in either cross-sectional or longitudinal studies 2) To collect total peripheral blood lymphocytes through either blood draws or leukapheresis procedures in order to obtain large numbers of cells for analysis. 3) To identify significant aberrancies in the phenotype and functions of NK cells and DCs that may further our understanding of the physiopathology of autoimmunity. 4) To better understand how innate and adaptive immunity are linked and whether aberrant interactions between the two arms of the immune system lead to the lack of immunological tolerance in autoimmune disorders, in order to develop alternative therapeutic approaches to autoimmune disorders 5) To develop new diagnostic tools that better characterize the status of innate immune competent cells and improve classification of the stages of autoimmune disorders, which could lead to a more effective use of immunosuppressive agents.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20100 Rozzano (Mi)
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.