Objective
Current strategies to repair damaged axonal pathways in peripheral nervous system (PNS), besides autologous nerve grafts, have concerned the application of bridging substrates that guide axonal regeneration across the lesion site. This IRG project is focused on the developing and evaluation of a series of novel guide channels based on biocompatible and biodegradable polymers for PNS regeneration. Natural polymers and their derivatives, and synthetic polymers: polyesters, e.g. poly(epsilon-caprolacotne), polycarbonates, e.g. poly(trimethylene carbonate), and polyester-ethers, e.g. polydioxanone will be examined in the form of blends, crosslinked and grafted material. Guidance tube manufacturing technology will include phase-inversion spinning, solution cast molding, radiation crosslinking, grafting by chemical and radiation method. Since these products are intended to be sterilized by radiation method, effects of irradiation on individual components and the complete biomaterials will be examined. In-vitro assessment of fabricated tubular guides, besides standard physicochemical tests, will include biocompatibility, biodegradability, bioactivity, etc. In-vivo animal trials of carefully chosen formerly examined in-vitro tube biomaterials are considered to be performed at collaborating institute in the final period of the project. This study will have remarkable impact on enhancement of the quality of life of EU citizens. Utilization of developed nerve guide channel implants, with tailored parameters and improved functionality, will shorten recovery period after surgery of PNS injuries and facilitate restoration of nerve functions. The new knowledge generated from this project will certainly contribute to the researcher’s career and competitiveness of EU in academic research fields as well as biomedical business, especially SME, in advanced high-technology sectors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry inorganic compounds
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
90 924 LODZ
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.