Objective
Type 2 diabetes is the most common metabolic disease and is characterized by insulin resistance in the liver, adipose tissue and skeletal muscle and impaired insulin secretion. Type 2 diabetes is a polygenic disorder which also involves environmental factors and is tightly correlated with obesity. Therefore, the identification of the genes associated with increased susceptibility to these diseases is difficult. At present, therapies for this disease are not completely effective and present secondary effects. To design new therapies, a better knowledge of molecular regulation of the expression of genes implicated in the pathology of diabetes is necessary. Gene regulation at transcriptional level has been demonstrated to be directly correlated, among other factors, with chromatin structure which may be altered by covalent modifications of NH2-terminal end of histones, mainly through acetylation. The balance between acetyl transferase (HAT) and deacetylase (HDAC) activities controls the histone acetylation status. Among HDAC enzymes, sirtuin 1 (SIRT1) has been shown to suppress glycolytic pathway and to induce gluconeogenesis in the liver, two of the main alterations in the diabetic process. Thus, modifications in the histone acetylation level may be involved in the onset and the development of diabetes. Therefore, the main objective of this project is the identification of target genes for SIRT1 by using ChIP-chip methodology (hybridization of specific promoter microarrays (chip) with the products of chromatin immunoprecipitation (ChIP). The contribution of these genes to the diabetic process will be further evaluated by the generation and the study of genetically engineered animals by gene transfer. The results of this study may contribute to a better understanding of the mechanisms of gene transcription regulation, which may lead to potential development of new therapies for type 2 diabetes and obesity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08193 Cerdanyola Del Valles
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.