Objective
Background: The DNA damage response (DDR) is a specialised stress response fundamental to maintaining genome integrity and suppressing tumour formation. Traditional molecular and cellular biology, combined with genetics and biochemistry, have led to an understanding of the architecture of the DDR in a variety of model organisms and in human cells. These studies have employed populations of cells/molecules and their results are of necessity an average of the response. High sensitivity imaging technologies make it feasible to study events in single cells and to do experiments with small numbers of molecules in vitro. These can now be applied to the DDR. Project Objectives: To provide an interdisciplinary training in single cell and single molecule studies to graduate students in Physics, Chemistry, LS, Maths and Computer sciences. The focus of the research will be the study of the DDR and genome stability. The main technologies to be developed concern high resolution molecular imaging methodologies. Specific aims: To train eight early stage researchers to doctoral level to utilize an interdisciplinary approach to address specific scientific questions and to communicate between disciplines. Study Design: We will achieve our objective by building a network comprising four “local” groups, each a collaboration between an imaging specialist and a cell biologist / molecular geneticists engaged in research on genome stability. The collaborating scientists will serve as co-advisors and will develop a personalised interdisciplinary research training programme for each recruit. Local training will be augmented by specially designed network-wide summer schools, workshops and meetings encompassing all network participants and invited experts. An industrial partner is integral to the network in order to share methods and provide secondments and input into workshops to train researchers in technology exploitation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences optics microscopy
- natural sciences computer and information sciences
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-1-1-ITN
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BN1 9RH BRIGHTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.