Objective
B cells produce antigen-specific antibodies as part of the adaptive immune response. This is the result of a complex process of activation and differentiation that is initiated with the specific engagement of the Ag to the BCR. While a wide range of studies have been performed in vitro to understand B cell-Ag recognition, we still understand very little about the basics of motility, compartimentalization and Ag recognition in vivo, because these events occur in densely packed lymphoid organs. Only recently the development of new microscopic techniques has allowed to analyze B cell behaviour in vivo in immune tissues. The main aim of this project will be to understand the molecular parameters that modulate Ag transport, presentation, uptake and B cell behaviour in the lymph node. We will move from an in vitro approach (studying follicular dendritic cells-B cells interactions and Ag presentation) to an in vivo analysis of B cell fate and Ag transport in the lymph node. These studies will allow us to shade light in the molecular parameters that regulate B cell behaviour. Moreover, the analysis of the role of innante immune receptors in in vivo B cell responses will lead us to integrate the effects of the complexity of the immune response in B cell behaviour. Antibodies have demonstrated their value as bio-therapeutics across a wide spectrum of diseases, such as cancer, immune disorders, and infection. Thus, understanding what signals are required to effectively activate B cells and the principles driving the selection of high affinity B cell variants are key for the successful generation of highly specific antibodies. This knowledge can be applied in the long term to the design of more specific and effective therapeutic antibodies for the treatment and diagnosis of infectious diseases and cancer. Moreover, a comprehensive map of B cell activation will help to understand the factors that lead to the development of autoimmune diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
E20 1JQ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.