Objective Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a process known as plasticity. Adults are therefore able to regain considerable function after stroke, and to compensate for the synapse and cell loss of Alzheimer’s disease until it reaches a critical level. Children undergo a period of enhanced plasticity in most parts of the CNS at the end of development, known as critical periods. During these periods their ability to compensate for damage to the CNS is in many cases much greater than in adults. The overall concept behind this application is that restoration of the function in neurodegeneration can be achieved through plasticity (the formation of new functional connections, withdrawal of inappropriate connections, modulation of synaptic strength). Promoting increased plasticity in selected parts of the adult nervous system back to the level seen in children is a powerful method of enhancing recovery of function in animal models. Plasticity-promoting treatments could therefore be beneficial in a wide range of conditions that damage the CNS. The PLASTICISE project integrates scientists from four scientific areas 1) Development of methods to promote plasticity 2) Development of models of neurodegenerative disease 3) Imaging of plasticity at the macro and micro level 4) Study of recovery of function through plasticity in human patients with brain disorders. The concept that unites the partners is the belief that treatments that enhance plasticity will become one of key medications that will improve neurological function in the damaged human nervous system. The purpose of the project is to bring this moment closer. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicineneurologystroke Keywords macro/micro imaging new animal models plasticity recovery of function Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.2.1-7 - Restorative approaches for therapy of neurodegenerative diseases Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE EU contribution € 871 931,92 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge United Kingdom See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaeffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all University of Zurich Switzerland EU contribution € 694 760,00 Address RAMISTRASSE 71 8006 ZURICH See on map Activity type Higher or Secondary Education Establishments Administrative Contact Anita Buchli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 338 360,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Maria Grazia Piga (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Netherlands EU contribution € 301 130,00 Address KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Cor Van Leeuwen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Novartis Forschungsstiftung Switzerland EU contribution € 338 930,00 Address Maulbeerstrasse 66 4058 BASEL See on map Activity type Research Organisations Administrative Contact Dorothy Searles (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 338 930,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Patrick Aebischer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 641 060,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kent Lee (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution € 338 930,00 Address RUE DU GENERAL DUFOUR 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Anthony Holtmaat (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM FREIBURG Germany EU contribution € 351 280,00 Address HUGSTETTER STRASSE 49 79106 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Gerhard Henninger (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK Poland EU contribution € 330 338,00 Address UL. LUDWIKA PASTEURA 3 02 093 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Administrative Contact Marta Rucinska (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 351 440,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Patrice Wegener (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PHARMAXON SAS Participation ended France EU contribution € 53 655,08 Address Parc Scientifique de Luminy 13288 MARSEILLE See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jean-Chrétien Norreel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data D-Pharm LTD Israel EU contribution € 14 400,00 Address SAPIR STREET 7 76123 REHOVOT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Tami Horovitz (Dr.) Links Contact the organisation Opens in new window Total cost No data DANDO WEISS & COLUCCI LIMITED United Kingdom EU contribution € 229 500,00 Address LOWER BRISTOL ROAD MINERVA HOUSE BA2 9ER BATH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jonathan Dando (Dr.) Links Contact the organisation Opens in new window Total cost No data NOVARTIS PHARMA AG Switzerland EU contribution € 2 400,00 Address LICHTSTRASSE 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Melissa Cooper Shinske (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. United Kingdom EU contribution € 2 400,00 Address Great West Road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stephen Sheldon (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data