Objective
Mental disorders put a great burden on society and their impact on personal life can be devastating. Most mental disorders begin in childhood or adolescence and co-occur with somatic disease. In children, the most common problems are ADHD and anxious/depression and these problems often co-occur with additional behavioral and emotional problems. In adults, depression is the major mental disorder. It frequently co-occurs with anxiety disorders, substance abuse, migraine, cardiovascular disease and its associated risk factors. Indeed, depression is the largest cause of nonfatal disease burden in Western countries and increasingly in low and middle income countries worldwide as well. This application focuses on the genetics of common mental disorders, co-morbid traits and diseases across the lifespan. Its primary aim is the discovery of developmental paths into risk of depression and co-morbid disorders, using genetic epidemiological, molecular genetic and gene-environment interaction models. The introduction of multivariate and longitudinal models, in particular methods introduced by my group, into these areas will lead to substantial increases in power to unravel the contributions of genotype, environment and their interactions. The project described in this application addresses three interrelated topics: 1. Neuropsychiatric disorders and cognition 2. Depression, anxiety, substance use, abuse and dependence 3. Depression, migraine and cardiovascular risk As a connecting methodological framework it will develop models for the genetic analysis of these complex traits, especially gene-environment interaction and genome-wide association models. My ambition is to discover which genes influence the risk for mental disorder and co-morbid biomedical traits, to identify the causal variants, and to explore their interaction with environmental risk factors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- medical and health sciences health sciences substance abuse
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine psychiatry anxiety disorders
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2008-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
1081 HV Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.