Objective A proposal for the concise synthesis of a family of cytotoxic natural products obtained from Polythia Crassa is contained herein. The short and highly effcient synthesis accesses all the structurally diverse family members from two simple common precursors. The synthesis makes use of novel tandem reaction sequences to access these molecules. The molecules and their syntheses are amenable to the inclusion of structural modifications and libraries of structurally diverse analogues will therefore be made using parallel synthesis techniques. Natural and synthetic compounds will then be tested against a panel of human tumour cell lines allowing iterative redesign of analogues to be undertaken in order to hone the activity and pharmacokinetic profile of promising lead compounds. Keywords biological evaluation compound library cytotoxicity diversity orientated synthesis natural products organic chemistry parallel synthesis synthesis tandem reaction sequence Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-2-2.ERG - Marie Curie Action: "European Reintegration Grants" Call for proposal FP7-PEOPLE-2007-2-2-ERG See other projects for this call Funding Scheme MC-ERG - European Re-integration Grants (ERG) Coordinator PANEPISTIMIO KRITIS EU contribution € 45 000,00 Address UNIVERSITY CAMPUS GALLOS 74100 Rethimno Greece See on map Region Νησιά Αιγαίου Κρήτη Ρέθυμνο Activity type Higher or Secondary Education Establishments Administrative Contact Eva Michelidaki (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data