Objective
Allogeneic haematopoietic stem cell transplantation (HSCT) is an important curative therapy for a large number of hematological diseases. Graft versus host disease (GVHD) remains the major complication of allogeneic HSCT, which occurs in 40-60% of transplant recipients and could be directly responsible for 25% of transplant related mortality and a significant proportion of transplant related morbidity. Established immunosuppressive treatments are of limited efficacy and have significant side effects. Extracorporeal Phototherapy (ECP) is an effective treatment for GvHD. Importantly, infection and relapse rates are not increased in the course of ECP treatment. Hence, ECP is an exciting model to study tolerance mechanisms. ECP actions include apoptosis, cytokine modulation and the induction of regulatory T cells but the underlying mechanisms have not been revealed yet. Antigen presenting cells like dendritic cells (DCs) are thought to be important in mediating ECP effects. The project aims at comprehensively analysing ECP effects with special focus on the modulation of dendritic cells by ECP induced apoptotic cells. A unique modified skin explant model simulating ECP treatment for GvHD will be used to analyse immunoregulatory characteristics of DCs and T cells modified by apoptotic cells. Proteins known to carry regulatory potential will be assessed and mRNA expression arrays will be used to identify novel molecules involved in tolerance. The project will furthermore explore if ECP induced apoptotic cells have unique properties by comparing different methods of apoptosis induction. The skin explant model will be used in an antigen-specific context to clarify whether ECP actions are T cell clone specific. The last part of the project will analyse DNA polymorphisms of molecules identified during the course of the project to predict reponses to ECP in patients. In summary, ECP will be used as a model to study tolerance and derive novel tolerogenic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine emergency medicine graft versus host disease
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-2-ERG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
50937 Koeln
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.