Objective
The gonadotropin hormones regulate reproduction, showing dynamic fluctuations in their expression levels across the life cycle to determine reproductive potential. The principle determinant of their expression is the hypothalamic hormone, GnRH, which stimulates both their synthesis and secretion. Aberrant GnRH exposure can stimulate precocious puberty, and we have shown previously that GnRH is able to overcome prolonged periods of gonadotropin gene repression, through removing histone deacetylases (HDACs) from their promoters. While HDACs repress transcription through nucleosome compaction, active histone acetylation on the protruding N-terminal tails of histones H3 and H4, both loosens the packaging of DNA and can serve as a signal for the binding of additional transcription factors. Research on the gonadotropins has revealed a number of transcription factors that activate both basal and GnRH-stimulated gene expression, but the role of the histone modifications has not been studied. The first aim of this study is to investigate which histone acetyl transferases (HATs) activate the gonadotropin gene promoters in response to GnRH treatment, whether they have any target specificity on the H3 and H4 tails, and how they are recruited. Histone acetylation is just one of the various covalent modifications which are required for activating transcription, although the regulation and interdependency of many of these modifications are not yet clear. We will therefore also study the requirement and consequence of the histone acetylation for other histone modifications such as phosphorylation and methylation at these gene loci. This is a novel aspect of GnRH signaling to the gonadotropin genes, that both provides a suitable model for understanding basic mechanisms of hormone-induced chromatin modifications, and also has implications for clinical relevance in the field of reproductive endocrinology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.