Objective "BLV200703/4 is a small molecule discovered jointly by groups from the University of Lisbon (Portugal) and Girona (Spain) that proved its efficacy in analgesia from behavioural tests in rats. The same molecule was tested in a platform that screens potential pharmacological molecules/compounds for neurodegenerative diseases with positive results. The platform is owned by Bioalvo, SA (Portugal). The preliminary results so far obtained regarding efficacy and toxicology of the molecule are encouraging and the academic inventors and the industrial developers are committed to take it into preclinical tests. However, a previous phase of lead optimisation is needed where a well devised strategy will make use of medicinal chemistry methodologies combined with robust in vitro and in vivo assays, in order to achieve the best pharmacological and ADME/toxicity characteristics for our lead molecule. This requires technology, knowledge and innovation transfer since the inventors and Bioalvo are unable to perform this endeavour on their own. Synovo, a German company expert in ADME/tox tests and the University of Tuebingen, with a group expert in Medicinal Chemistry, joined Bioalvo and the Universities of Lisbon and Girona to transfer all knowledge, technology and innovation necessary to make possible that BLV200703 or one of its future derivatives reaches pre-clinical stage. This project fits the ""Developability Assessment Logic Plan"" of BLV200703 as established with a consulting company expert in drug development. Not only all the participants are committed to the success of this product development, they are also committed to two-ways exchange of information and technology that strength their activity in the future. For instance, in the end of this project Bioalvo SA will have a MedChem unit that will strength future development of new products and the Universities of Lisbon and Girona will be able to carry out basic early toxicology tests as part of their research." Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicinetoxicology Keywords early toxicity lead neurodegenerative diseases pain pre-clinical Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IAPP-2008 - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-IAPP-2008 See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES EU contribution € 248 037,00 Address AVENIDA PROF EGAS MONIZ 1649 028 Lisboa Portugal See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Administrative Contact Miguel Castanho (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOALVO S.A. Portugal EU contribution € 84 942,00 Address Edifício ICAT, Campus da FCUL, Campo Grande 1749-016 Lisbon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patricia Calado (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT DE GIRONA Spain EU contribution € 107 603,00 Address PLACA SANT DOMENEC 3 17004 Girona See on map Region Este Cataluña Girona Activity type Higher or Secondary Education Establishments Administrative Contact Bardaji Eduard (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYNOVO GMBH Germany EU contribution € 123 876,00 Address Paul Ehrlich Str 15 72076 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Burnet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 95 437,00 Address GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Stefan Laufer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data