Cel BIOFORCE has a highly ambitious applied objective: to create transgenic cereal plants that will provide a near-complete micronutrient complement (vitamins A, C, E, folate and essential minerals Ca, Fe, Se and Zn) for malnourished people in the developing world, as well as built-in resistance to insects and parasitic weeds. This in itself represents a striking advance over current efforts to address food insecurity using applied biotechnology in the developing world. We will also address fundamental mechanistic aspects of multi-gene/pathway engineering through transcriptome and metabolome profiling. Fundamental science and applied objectives will be achieved through the application of an exciting novel technology (combinatorial genetic transformation) developed and patented by my research group. This allows the simultaneous transfer of an unlimited number of transgenes into plants followed by library-based selection of plants with appropriate genotypes and phenotypes. All transgenes integrate into one locus ensuring expression stability over multiple generations. This proposal represents a new line of research in my laboratory, founded on incremental advances in the elucidation of transgene integration mechanisms in plants over the past two and a half decades. In addition to scientific issues, BIOFORCE address challenges such as intellectual property, regulatory and biosafety issues and crucially how the fruits of our work will be taken up through philanthropic initiatives in the developing world while creating exploitable opportunities elsewhere. BIOFORCE is comprehensive and it provides a complete package that stands to make an unprecedented contribution to food security in the developing world, while at the same time generating new knowledge to streamline and simplify multiplex gene transfer and the simultaneous modification of multiple complex plant metabolic pathways Dziedzina nauki medical and health sciencesmedical biotechnologygenetic engineeringgene therapyagricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingmedical and health scienceshealth sciencesnutritionnatural sciencesbiological scienceszoologyentomologyagricultural sciencesagriculture, forestry, and fisheriesagriculturegrains and oilseedscereals Słowa kluczowe Biofortification developing countries food security herbicide tolerance insect resistance maize minerals rice vitamins Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS9 - ERC Advanced Grant - Applied life sciences and biotechnology Zaproszenie do składania wniosków ERC-2008-AdG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Koordynator UNIVERSIDAD DE LLEIDA Wkład UE € 2 290 046,00 Adres Placa victor siurana 1 1 25003 Lleida Hiszpania Zobacz na mapie Region Este Cataluña Lleida Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Josep M. Sentis Suñé (Mr.) Kierownik naukowy Paul Christou (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSIDAD DE LLEIDA Hiszpania Wkład UE € 2 290 046,00 Adres Placa victor siurana 1 1 25003 Lleida Zobacz na mapie Region Este Cataluña Lleida Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Josep M. Sentis Suñé (Mr.) Kierownik naukowy Paul Christou (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych