Objective
Netrins were described as bifunctional guidance cues, capable of attracting or repelling developing axons via activation of receptors of the deleted in colorectal cancer (DCC) and uncoordinated 5 (UNC5) families, respectively. Recently, they have also been implicated in the process of blood-vessel formation or angiogenesis, where they may also act as bifunctional cues, but their effect is unclear, with previous reports showing contradictory endothelial behaviors. In order to clarify the pro- or anti-angiogenic role of the signaling pathway initiated by netrins on endothelial cells, combined in vitro and in vivo approaches will be pursued. We will be focused on the cellular situation previous to the stimulation of different types of endothelial cells. Homogenous populations on arterial, venous and microvascular endothelial cells will be analyzed. We will carry out a compared screening of mRNA levels on resting, proliferating or differentiating endothelial cells, on situations of netrin1 or 4 stimulation and baseline. Expression pattern of candidate molecules differentially regulated will be further characterized in developing zebrafish and mice by in situ hybridization. To rule out the active role of those molecules during developmental angiogenesis, the candidate will study their role on zebrafish development by both loss- and gain-of function approaches, using new powerful genetic tools. These genetic studies will be complemented with in vitro assays to document the navigation of endothelial tip cells and how gene up- down-regulation can affect the tip/stalk behavior, to dissect the pro- or anti-angiogenic signaling pathways induced by netrin1 and 4.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine oncology colorectal cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9052 ZWIJNAARDE - GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.