Objective The recent technical improvements for the study of the cytogenetic basis of disease have led to the identification of many microdeletion and microduplication syndromes. De novo copy number variants (CNVs) are seen more often than expected in autistic patients, and rare chromosomal aberrations are known to account for a small fraction of schizophrenia and bipolar disorder. Recurrent spontaneous mutations at multiple sites across the genome may be a prime cause of these disorders, and the reduced fertility associated particularly with autism and schizophrenia may, through selection pressure, maintain these variants at very low frequency. CNVs are large enough to be identified using cost efficient genome-wide search techniques, such as oligonucleotide arrays. In contrast, rare DNA mutations might confer a large proportion of the overall genetic risk, but cannot be easily identified at the present time. Genetic epidemiology suggests that autism, bipolar disorder, and schizophrenia are highly heritable and share susceptibility genes. However, the results of dense SNP array-based genome wide association scans for these disorders have been disappointing, as no high frequency risk alleles have been identified. The PsychCNVs consortium will apply oligonucleotide arrays for the large-scale interrogation of CNV variation in the human genome, focusing on people with autism and childhood onset schizophrenia and bipolar disorder, where CNVs are likely to be more common. This project follows on logically from our hypothesis-independent genome-wide SNP search for common variants, we now intend to systematically search for large, rare CNVs conferring high risk. The genetic risk conferred by CNVs will be estimated by genotyping samples from 2800 patients, to identify de novo or recent spontaneous mutations. Until low cost whole genome sequencing becomes available this approach offers the best current hope to identify causative genomic variants for these disorders. Fields of science medical and health scienceshealth sciencespublic healthepidemiologysocial sciencessociologydemographyfertilitynatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencesbiological sciencesgeneticsgenomes Keywords Autism Bipolar disorder Children Psychosis Schizophrenia Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.2.1-10 - Childhood and adolescent mental disorders Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ISLENSK ERFDAGREINING EHF EU contribution € 761 558,00 Address Sturlugotu 8 101 Reykjavik Iceland See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bjorgvin Richardsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all LANDSPITALI UNIVERSITY HOSPITAL Iceland EU contribution € 160 500,00 Address Eiriksgata 5 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Administrative Contact Hannes Petursson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution € 569 940,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact David Collier (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIONAL RESEARCH CENTER OF MENTAL HEALTH - RUSSIAN ACADEMY OF MEDICAL SCIENCES Russia EU contribution € 545 400,00 Address Kashirskoe sh 34 115522 Moscow See on map Activity type Research Organisations Administrative Contact Vera Golimbet (Dr.) Links Contact the organisation Opens in new window Total cost No data UKRAINE RESEARCH INSTITUTE OF SOCIAL AND FORENSIC PSYCHIATRY AND DRUG ABUSE OF THE MINISTRY OF HEALTH Ukraine EU contribution € 240 600,00 Address Frunze street 103 04080 Kyiv See on map Activity type Research Organisations Administrative Contact Igor Martsenkovsky (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Tbilisi State Medical University Georgia EU contribution € 240 600,00 Address Vazha-pshavela ave 33 0177 Tbilisi See on map Activity type Higher or Secondary Education Establishments Administrative Contact Irakli Evdoshvili (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY CLINIC OF PSYCHIATRY North Macedonia EU contribution € 240 600,00 Address Ul belgradska b b Skopje See on map Region Северна Македонија Северна Македонија Скопски Activity type Research Organisations Administrative Contact Antoni Novotni (Prof.) Links Contact the organisation Opens in new window Total cost No data INSTITUT ZA MENTALNO ZDRAVLJE Serbia EU contribution € 240 600,00 Address Palmoticeva 37 11000 Beograd See on map Region Србија - север Београдски регион Београдска област Activity type Research Organisations Administrative Contact Smiljka Popovic Deusic (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data