Objective
Recent studies suggest that the microenvironment surrounding primary tumor cells can temporarily change tumor cell gene expression, resulting in suppressed cell proliferation and increased cell motility. This genetic program allows tumor cells to invade the surrounding tissue, metastasize to distant parts of the body and suppress apoptosis induced by changes in the environment. Once cells reach a favorable milieu, they suppress migration, reactivate the proliferation program and expand in the target organ. Although many components involved in this switch between proliferative and migratory phenotypes have been identified, the precise molecular mechanism remains unknown. One of the protein shown to be specifically overexpresed in migratory but not in proliferating cells is adaptor/scaffold protein RACK1. We recently identified RACK1 as a scaffold-like protein in the ERK pathway which controls ERK activation and targets active ERK to specific intracellular compartments. My preliminary evidence indicates that the expression level of RACK1 correlates with the cell's ability to either migrate or proliferate. Thus, RACK1 may serve as a key molecular “switch” that controls whether ERK signaling regulates the proliferative or the migratory program. The goal of this research proposal is to understand how RACK1 and the ERK pathway regulate the switch between proliferative and migratory phenotypes and the contribution this “migratory switch” has on the development and progression of colorectal cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology colorectal cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
142 00 Praha 4
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.