Objective
The main objective of this project is to create a new generation of smart biomaterials with great potential for tissue engineering and controlled drug delivery. Supramolecular polymers based on quadruple hydrogen bonding ureido-pyrimidinone (UPy) moieties (developed by the host group of Prof. Dr. E. W. Meijer in Eindhoven University of Technology, the Netherlands) will be employed as a basic scaffold. To fulfill the biomaterials trinity, namely tuneable mechanical properties, biodegradability and bioactivity, we propose a unique approach to functionalize the biomaterial scaffold in order to generate biomedical activity. The combination of dynamic covalent chemistry (developed by the group of Prof. Dr. Jean-Marie Lehn in Louis Pasteur University, France where the applicant comes from) and non-covalent UPy-UPy hydrogen bonding allows for a modular (self-assembly) and orthogonal (self-sorting) approach to control cellular behaviour and activity both in vitro and in vivo. Due to their dynamic characters on both non-covalent and reversible covalent levels, they can be considered as constitutional double dynamic biomaterials, capable of response to different external stimuli (pH, temperature etc.), thus behaving as adaptive biomaterials. The results that will emerge from the current proposal are of particular interest for the fields of regenerative medicine and controlled drug delivery, which have a remarkable impact in human health care. This project will initiate the first cooperation between the host group and the group the applicant comes from, to tackle a major challenge for chemical biologists. Hence, it will contribute to European research and transfer of knowledge.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology tissue engineering
- natural sciences chemical sciences polymer sciences
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.