Obiettivo The symptoms of complex disease like allergy, obesity and cancer depend on the products of multiple interacting genes. High-throughput techniques have implicated hundreds of genes. There are also considerable individual variations. A clinical implication of this may be inadequate treatment response, which is increasingly recognized as a cause of increased suffering and costs. Ideally, physicians should be able to routinely personalize medication based on a few diagnostic markers. Finding such markers is a formidable challenge. We hypothesize that translational clinical studies based on high-throughput genomics, advanced computing and systems biology may help to identify markers for personalized medication in complex diseases. We organize disease-associated genes in networks that are analyzed in a top-down manner. First, modules of interacting genes with distinct biological functions are identified. Then the modules are dissected to find pathways and finally upstream genes with key regulatory functions. We use bioinformatic methods that were recently described by us in Nature Genetics and Nature Biotechnology. An important focus of this project is to develop these methods to form multi-layer modules that integrate information about disease-associated changes on the DNA, RNA and protein levels. Since these levels interact, studies of the different levels can be interactively used to cross-validate the modules. This involves both genetic and experimental studies, but the ultimate test of the modules will be if they can be used for clinical predictions. For example, changes in RNA expression may be caused by a single nucleotide polymorphism (SNP) in a regulatory region. If so, the corresponding protein is tried as a marker to personalize medication. We have chosen hay fever as a model of complex disease because it is common, well-defined and readily examined in clinical and experimental studies. However, the methods may be generally applicable to complex diseases. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticsRNAmedical and health scienceshealth sciencesnutritionobesity Parole chiave allergic rhinitis allergy microarrays systems biology Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Invito a presentare proposte FP7-HEALTH-2007-B Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore Linköping University Contributo UE € 492 991,20 Indirizzo Campus valla 581 83 Linköping Svezia Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Helena Blackert (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto THE UNIVERSITY OF TENNESSEE Stati Uniti Contributo UE Nessun dato Indirizzo White avenue 1534 37996 1529 Knoxville Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo E. Christine Cox (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Regno Unito Contributo UE € 353 640,00 Indirizzo South kensington campus exhibition road SW7 2AZ London Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Michael Robinson (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CENIX BIOSCIENCE GMBH Germania Contributo UE € 166 800,00 Indirizzo Tatzberg 47 01307 Dresden Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Karen Huppertz (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato GOETEBORGS UNIVERSITET Svezia Contributo UE € 777 537,80 Indirizzo Vasaparken 405 30 Goeteborg Mostra sulla mappa Regione Södra Sverige Västsverige Västra Götalands län Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Margareta Ahlqwist (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato OSLO UNIVERSITETSSYKEHUS HF Norvegia Contributo UE € 734 919,00 Indirizzo Kirkeveien 166 tarnbygget 0450 Oslo Mostra sulla mappa Regione Norge Oslo og Viken Oslo Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Gunhild Mælandsmo (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato