Objective
Obesity is a global epidemic. The number of people who are obese or overweight increases annually. Being obese or overweight significantly increases the risk of co-morbidities that are currently amongst the major health problems of modern times, including diabetes and cardiovascular disease, collectively known as the metabolic syndrome. Currently 2-7% of European healthcare budgets are consumed addressing health problems arising from excess body weight, and this is predicted to increase. Body weight regulation is complex. In order to find successful therapeutic interventions it is essential that we understand the molecular basis and mechanisms of appetite and energy balance regulation. For decades thyroid hormone deficiency has been known to cause obesity. It has been assumed that the principal cause of obesity by hypothyroidism is reduced energy expenditure in peripheral tissues. But there is now compelling evidence that thyroid hormone has a direct role in regulating neural mechanisms involved appetite and energy expenditure. The objectives of this project are 1. To show that T3 chronically released in the hypothalamus of the rat causes increased food intake, body weight with potential to develop into metabolic syndrome. 2. To identify thyroid hormone-regulated genes involved in hypothalamic control of appetite and energy balance. These objectives will be met by using state-of-the-art approaches including brain implant technology and microarray analysis of hypothalamic gene expression. The work will be carried out at the University of Aberdeen Rowett Institute of Health and Nutrition, an institute with a wealth of experience in nutrition research. The project is expected to provide significant new information on involvement and mechanism of thyroid hormone in appetite and energy balance, and to contribute to priorities identified in EU work programmes of FP5, FP6 and the current FP7 work programme for Health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AB24 3FX Aberdeen
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.