Objective
The presence of carbohydrate structures on the surface of proteins has been estimated to occur in more than 50% of eukaryotic cells, and is linked to several biological events such as cell signalling regulation, cellular differentiation and immune response. Of the three classes of biooligomers, oligosaccharides have proven to be the most difficult to synthesize. Studies concerning the structure and function of oligonucleotides and peptides have greatly benefited from the feasibility of conducting their assembly on polymeric supports. In order to simplify the labor-intensive solution phase synthesis of carbohydrates, assembly of such compounds in an automated fashion on solid support is particularly desirable. Well-defined, synthetic carbohydrates not only constitute excellent research tools to investigate the structure and function of these biopolymers, but also hold great promise as potential therapeutic agents or vaccines against tumors and infectious diseases. Proposed is a program targeted at the synthesis of sialylated oligosaccharides that serve as receptors of avian and human influenza virus. Like other viruses, influenza viruses use interactions between a viral surface protein and well-defined cell surface oligosaccharides to initiate infection. Herein, we propose to prepare sialyl pentasaccharides by automated solid phase synthesis. The resulting complex carbohydrate structures will be attached to microarray slides that will be further subjected to binding experiments with different influenza virus hemagglutinin proteins. These glycan arrays will serve as molecular tools to understand important recognition and signal transduction processes of the infection mechanism by the influenza virus. The results obtained from these binding tests have the potential to create novel carbohydrate-based diagnostics and therapeutics for the influenza virus.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 Munchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.