Objective
Inflamatory bowel diseases (IBD) are systemic diseases characterized by intestinal inflamation and extra-intestinal manifestations. The compartimentalisation of inflammatory processes is driven by immunological mechanisms, in particular pertaining to homing and trafficking of immune cells. Intestinal Dendritic Cells (DC) are professional antigen presenting cells that recognize antigens and direct subsequent immune response. DC also dictate the type of T-cell immune response (e.g. pro-inflamatory or regulatory). In health, intestinal DC contribute to induction of immunological tolerance and control of immune activity in the gut. The Host Laboratory has provided evidence for the importance of immune compartmentalisation in IBD patients, since they have demonstrated an increased number of DC in inflamed mucosa of patients with IBD, increased activation of DC, and increased expression of both immune receptors and increased production of pathologically-related cytokines. Also, gut-homing DCs mark T-cells they stimulate with gut-homing markers. HYPOTHESIS In IBD, aberrant DC populations drive homing and functions of pathogenic T cells. AIMS 1. To examine changes in IBD (with and without extraintestinal manifestations) in the homing marker expression of DC 2. To identify the homing and functional properties of T-cells stimulated by subpopulations of DC in IBD. ANTICIPATED OUTCOMES In inflamed tissue, intestinal DC will have different homing markers and/or changed capacity to induce “gut homing” T cells. These changed profiles could be linked with different phenotypes of disease in patients with IBD. A greater understanding of this “post-code” system in DC and T-cells may lead to refinement of current therapies and development of more rational therapies for diseases at different anatomical sites and for different diseases, since it would be possible targeting the more easily accessible blood DC and T-cells destined to produce inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences basic medicine immunology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.