Objective
Boundaries among biological, chemical and physical domains are nowadays fading, and the complex phenomena observed in Nature as well as in artificial systems can only be tackled from a broader/interdisciplinary perspective. In this context, the biological activation of the molecular oxygen is a fascinating and yet complex process. The ability to store, transport and utilize this simple molecule gated evolution of life in our planet and led to growth and selection of a variety of organisms. Complex molecules selected by Nature as active in “key metabolic paths” of the oxygen in life often contain copper and/or iron metal ions as reactive centres. A wide variety of experimental results and theoretical investigations show that the metallo-oxygen interactions have dominant states that are not spatially homogeneous (anisotropy). These effects occur when a number of physical interactions such as spin, charge, lattice (crystal-field), and/or orbitals are simultaneously active. The result of these interlocked numbers of factors links biology to chemistry and molecular physic, and allow the oxygen to be used in different ways within metabolism. The research proposal presented herein aims to investigate the red/ox mechanism and the connected energetic of the oxygen activation process in a series of di-iron (Ribonucleotide Reductase, RNR, Class I R2) and copper protein (multicopper oxidases) through the use of spectroscopic methods (EPR X-Q, high field EPR, CD, MCD, rR resonance Raman), structural (X-ray) and kinetic analyses (stopped flow, cryoenzymology). The endeavour is directed towards a better understanding of the geometric and electronic structure of metal-oxygen interactions that contribute to define O2 reactivity. These studies will provide molecular level insight into oxygen and metal metabolism, disease states, bioremediation and possible the development of efficient drugs inhibitor.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology environmental biotechnology bioremediation
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences astronomy planetary sciences planets
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
0313 Oslo
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.