Objective
The maintenance of genomic integrity is a crucial biological process. Among the main factors influencing genome stability are DNA repair mechanisms, which are highly conserved among eukaryotes. There is a complex interplay and crosstalk among the different regulatory mechanisms that control DNA repair pathways. These mechanisms often exploit post-translational modifications such as ubiquitination and sumoylation. The recent discovery of the evolutionarily conserved family of SUMO-targeted Ubiquitin ligases (STUbL) has established a novel mode of communication between the sumoylation and ubiquitination pathways. In addition, recent evidence has implicated the sumoylation pathway and STUbLs as important players contributing to subnuclear architecture. This project aims to understand the mechanisms by which ubiquitination/sumoylation, subnuclear localization and DNA repair interface to maintain genome integrity. Recent data from the Gasser lab has identified the relocalization of damage to nuclear pores as a novel event that contributes to repair by a complex of nuclear pores and Slx5-Slx8 (the budding yeast STUbL). This proposal will focus on the characterization of molecular mechanism through which Slx5-Slx8 regulates DNA repair. We want to understand how ubiquitin/SUMO modification affects eukaryotic nuclear organization during DNA repair. We combine yeast molecular genetics, biochemical methods and quantitative live fluorescence imaging approaches to address these questions at a molecular level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences molecular biology molecular genetics
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4058 BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.