Objective
Understanding how biochemical signaling networks encode biological specificity is a fundamental challenge for biologists in the 21st century. Genome sequences by providing the “parts list” for such signaling networks, were expected to advance insight. However, it has become clear that to understand specificity analyzing only the “parts list” is not enough; it is the complex orchestration of these parts’s expression, interactions, activation, and deactivation in both space and time that encode biological specificity. Thus, understanding the biological specificity code requires investigating the spatiotemporal dynamics of biochemical signaling networks. This proposal focuses on understanding how the spatiotemporal dynamics of epidermal growth factor (EGF) gradient-induced signaling and associated feedback loops encode a cell’s decision to migrate and invade. A particular focus is on the isoform-specific roles of ERK1, ERK2, Akt1, and Akt2. Traditionally, these protein isoforms have been assumed to have very similar roles in the phenotypic response to EGF signaling. However, our preliminary data show that these isoforms have very distinct, opposing roles for control of EGF gradient-induced cell migration in an aggressively migrating mammalian cell line. To measure, interpret, and understand EGF gradient-induced signaling and the resultant cell migration, we propose using an interdisciplinary, systems biology approach combining modern biochemistry, quantitative mass spectrometry, live-cell imaging, spatially-resolved mechanistic modeling, and empirical data-driven modeling. Model-based experimental design will be the hub that connects modeling with experiments through an iterative model building cycle. As result we hope to gain a mechanistic understanding of how EGF gradient signals are spatially propagated through a cell, coupled with the ability to predict cell migration outcomes based on the spatiotemporal signaling patterns.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences cell biology cell signaling
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.