Objective
Fetal programming of mental and cardiovascular diseases by adverse prenatal environmental influences is a main issue of developmental medicine. However, the number of measurable functional parameters in the human fetus is limited. The assessment of key parameters of the underlying processes of fetal brain maturation could foster the early detection of developmental problems, the design of therapeutic strategies and save immense cost for public health. Biomagnetic measurements of fetal heart rate patterns (HRP) and fetal auditory evoked responses (fAER) may open a new non-invasive diagnostic window. Up to now the signal to noise ratio of these recordings is non-sufficient and they are too short for an appropriate consideration of fetal state behaviour. Consequently reliable clinical studies reflecting developmental disturbances could not be performed. The goal of the project is two-fold: (1) to improve the identification of fetal heart beats and fAER in longer and non-stationary recordings, (2) to explore for the first time simultaneously behavioural state dependent HRP, indices of fetal heart rate variability and reliable fAER indices; both appropriate to data of a longitudinal study involving intrauterine growth restriction (IUGR) and antenatal steroid (glucocorticoid GC) administration. This will be achieved by innovative developments of advanced signal separation and identification methods to improve the signal to noise ratio in the biomagnetic recordings and novel signal analysis approaches best suited for nonlinear and nonstationary signals. The host group provides a unique data bank of functional, clinical and biomagnetic measurements from normal fetuses and those with possibly developmental disturbances by IUGR or GC. The developed methods will be evaluated on the study data set mentioned above and will be prerequisite for a significant improvement of the signal quality, reduction of dropouts and the design of advanced indices of fetal brain development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine obstetrics fetal medicine
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
07747 JENA
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.