Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS
Content archived on 2024-06-18

FoldAmeRs : a new family of G-QUADruplex ligands

Objective

This proposal focuses on the formation of complex between DNA G-quadruplexes and a new family of synthetic ligands, which might be relevant for cancer therapy. The enzymatic acitivity of telomerase is critical to the immortality of most human cancer cell lines. However, telomeric DNA may fold into guanine quadruplex structures which are not competent substrates for telomerase. Therefore, the use of small molecule ligands to induce quadruplex stabilisation in telomeric DNA has potential as an anti-cancer strategy. A European collaboration recently engaged between I. Huc (Bordeaux, France) and S. Balasubramanian (Cambridge, UK) groups already led to the identification of a very promising compound, with exceptionnal potential for stabilising human G-quadruplex telomer. In addition a three dimensionnal helical compound (foldamer) has shown interesting activity. This project, involving chemistry, biology and biophysic, aims i) to systematically design and develop new analogues of this promising candidate, based on aromatic delta-peptide chemistry; ii) to evaluate their G-quadruplex binding affinity in telomere and others systems; iii) to establish structure-activity relationships; iv) to determine the key elements necessary for specific G-quadruplex recognition by solving the structure of the first ligand complexed with G-quadruplex. This original interdisciplinary proposal involves two international leading groups in their respective field, to develop new tools and knowledge on the growing interest on natural G-quadruplexes as new target for anti-cancer strategy. The applicant will have a crucial role in the development of this collaboration and will become an active and efficient third partner, when returning back to China at the end of the fellowship.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

You need to log in or register to use this function

Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-IIF-2008
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSITE BORDEAUX I
EU contribution
€ 174 535,75
Address
351 Cours de la Liberation
33405 TALENCE
France

See on map

Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data
My booklet 0 0