Objective
The objective of the project is to understand the role of the centrosome in the life cycle and assembly process of the human immunodeficiency virus (HIV), the causative agent of AIDS. The aims are to delineate the viral and host factors, which define this interaction and to seek promising drug targets for novel antiviral approaches to HIV. A number of stages in the HIV life cycle are currently targeted for therapeutic attack. As yet, none of these involve the virus assembly process or the subcellular trafficking pathway. Recent evidence concerning early stages of assembly implicates the centrosome of the cell and some highly conserved viral components. The methods involved will be in vivo imaging, including selected mutants of the virus, and genetic and biochemical analyses. These latter will involve RNA analysis, subcellular fractionation of centrosomes, proteomic profiling and mass spectrometry to identify proteins interacting with the virus. The study is highly relevant since the AIDS epidemic continues to spread globally and there is no evidence of a vaccine as yet. Despite a number of good antiviral drugs, these can only control and not eliminate the virus and there is growing evidence of viral resistance to the currently available drugs and a significant level of patient intolerance to these. Thus, there is an urgent need for more therapies targeting different stages of the viral infection. The work will contribute to health and wealth creation in the European Union by improving its scientific research base and opening up new translational targets. It will also, ultimately, contribute to global improvements in health, especially in the developing world where the AIDS epidemic is most serious.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences chemical sciences analytical chemistry mass spectrometry
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.