Objective Existing spectroscopic methods do not provide satisfactory data on structure, orientation and interactions of biomacromolecules in their native environments. This is especially true of membrane proteins, a major class of drug target. The structure of formulated glycoprotein biopharmaceuticals and their interactions with their targets are also a challenge for UV spectroscopies due to extremely high concentrations and the near invisibility of the sugars to UV radiation. Infra red methods suffer from water absorbance dominating the analyte signals. We will therefore develop a new technique called flow-aligned polarised Raman (FAPR) spectroscopy, which will have many of the advantages of existing techniques, including using aqueous environments, while avoiding their pitfalls by using visible radiation. We expect to gain new structural data on the studied molecules using FAPR. The applicability of this method will be verified on membrane peptides and proteins and glycoproteins. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopy Keywords Chemical physics Chemistry Instrumental techniques Physical sciences Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Call for proposal FP7-PEOPLE-IEF-2008 See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE UNIVERSITY OF WARWICK EU contribution € 181 350,76 Address Kirby Corner Road - University House CV4 8UW Coventry United Kingdom See on map Region West Midlands (England) West Midlands Coventry Activity type Higher or Secondary Education Establishments Administrative Contact Peter Hedges (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data