Objective
CD44 is a type I transmembrane glycoprotein highly polymorphic expressed in most tissues. The single gene can give rise to many different transcripts, named CD44 variants. CD44 represents the principal receptor for the main matrix glycosaminoglucan component, the hyaluronic acid (Ponta et al., 2003). CD44 is a multifunctional protein involved in lymphocyte homing and activation, cell migration or apoptosis. CD44 functions are modulated by metalloproteases that cleave the extracellular part of CD44, giving rise to a soluble form. The remaining transmembrane part of CD44 can be further cleaved by gamma-secretase resulting in the liberation of the C-terminus tail, called CD44ICD (intracellular domain), which translocates to the nucleus. Although, the functions of CD44ICD are not yet understood, it has been shown that it can potentiate its own transcription in a p300/CBP dependant manner (Okamoto et al., 2001). Recent work from Manié and colleagues has shown that CD44ICD per se possesses a transforming activity which is actively participating in the oncogenesis induced by the oncogenic form of Ret MEN2A (Multiple Endocrine Neoplasia type 2A, characterized by medullary carcinoma in the thyroid), revealing a new function for CD44ICD in tumorigenesis (Pelletier et al., 2006). Interestingly, they also observed that CD44ICD potentiates NF-κB transcriptional activity in the context Ret-MEN2A, which is particularly interesting because NF-κB was shown to be an important mediator of cellular transformation by MEN2A (Ludwig et al., 2001) (unpublished data). Finally the group also detected CD44ICD in several human tumoral tissues including colon carcinoma. Altogether these data suggest a new role for CD44 in carnogenesis. The aim of the present project will be to characterize the molecular mechanisms through which CD44ICD promotes cell transformation by investigating the molecular partners and the transcriptional targets of CD44ICD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-ERG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.