Objective
"Most toxic metals and radionuclides can be naturally rendered insoluble-immobile by bacterial reduction, which may be exploited for bioremediation purposes at waste repository sites. Some bacteria (e.g. iron or sulphate respirers) are receiving intense attention as their envelope-located electron transport chain can carry out such reductions. However, this process is subject to inhibition by nitrate and oxygen, usually present at waste sites. It also involves 1 e- transfer reactions generating reactive oxygen species which poison the cells and hamper remediation, and the reduced species are released outside the cells, where re-oxidation may occur rapidly. An alternative ""safe"" bacterial pathway for reduction of metals-radionuclides has been discovered recently at the host laboratory (Dr. AC Matin). It involves proteins from the widely distributed ChrR enzyme family, performing 2 e- (4 e-) transfer processes strongly reducing oxidative stress, and leads to sequestering of reduced species. Strengthening this pathway should lessen metal toxicity and increase bioremediation capabilities. The objectives of this multidisciplinary project are (1) to assess this reduction process in bioreactors simulating waste sites conditions, using an engineered strain producing a highly improved ChrR, by analysing the oxidation state and distribution of reduced products; (2) as minor mutations of ChrR led to its increased efficiency, to test the hypothesis that improved ChrR activity is naturally present at US waste sites, where bacteria have been exposed to metals for over 50 years; (3) to test if the intra-cellular reduced products are indeed less amenable to re-oxidation than extra-cellular ones; and (4) to use the skills gained for the identification of new cytoplasmic enzymes with safe metal reduction mechanisms in uranyl-rich soils from Bessines (France), where bacterial communities with effective means of safe enzymatic reduction of uranyl are likely to have naturally evolved."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-1-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75015 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.