Objective
Human Embryonic Stem Cells (hESCs) harbour the extraordinary ability to self-renew and differentiate into cells of all tissue types and thus, hold great promise for the treatment of a range of diseases. Mechanisms controlling hESC fate are yet to be elucidated but are believed to involve regulation by intrinsic and extracellular metabolic factors including hormones, growth factors and small cell-permeable molecules. High resolution proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy is a powerful, non-invasive technique that can be used in conjunction with statistical modeling methods to characterize perturbations in metabolic pathways that occur during cellular events. This approach, termed ‘metabonomics’, can also be used to acquire a metabolic fingerprint of a cell at a particular time point or state. Such information can be used for better comprehending underlying cellular events as well as for cell-type classification. In this project, NMR-based metabonomics will be employed to realise two main objectives; 1) identification and characterisation of metabolic factors involved in hESC differentiation, and 2) cell-type classification of differentiated hESCs. These objectives are closely interrelated as the elucidation of factors controlling stem cell fate would provide the means for “directed cellular differentiation” and prove invaluable for regenerative medicine and drug discovery applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
46012 Valencia
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.