Objective
The past year has been exciting for oligonucleotide-based drug discovery and development. The Nobel Prize was awarded to Mello and Fire for discovering RNA interference. There was also big investment from the Pharmaceutical industry to Biotechnology companies-pioneers in oligonucleotide therapeutics such as Sirna, Alnylam and Isis, all US-based. High expectations were therefore raised but further progress is hampered by the issue of systemic delivery; siRNA oligonucleotides are ineffective in vivo whereas antisense DNA oligonucleotides can be effective for liver-specific targets only. Therefore, delivery systems are a matter of intense investigation with the most recent advances being cationic liposomes with PEGylation or diffusible PEGylation. However, these carriers face tolerability issues, non-specific immune stimulation or limited biodistribution. Novosom has developed a completely novel carrier system based on amphoteric liposomes. This incorporates structural features with unique charge-reversal properties which result into safety and performance advantages over the current best alternative carriers. The aim of this Consortium is to built on Novosom’s carrier technology to develop novel improved amphoteric liposomes with targeted delivery modalities to cells of the immune system, and to apply them for therapeutic oligonucleotide delivery to inflammatory diseases. Knowledge transfer between partners will facilitate the design of novel carriers, identification of targets and validation using in vivo models of inflammatory disease. The Consortium stems from two very successful one-to-one collaborations and proposes here a fully integrated program of translational, interdisciplinary research. Knowledge transfer between Novosom, a European leader in oligonucleotide delivery technologies, and two Academic Institutions of international standing in inflammatory disease therapeutics provides the competitiveness needed for a European team in this US-dominated field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences health sciences inflammatory diseases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IAPP-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)
Coordinator
115 27 Athina
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.