Objective
Chronic inflammation is a common feature in diseases like primary immunodeficiencies and autoimmunity. It is the consequence of the inability of the immune system to regulate and resolve the inflammatory process. Even though significant advances have been made in the past years to understand some of the mechanisms involved in chronic inflammation, which lead to the development of therapeutic strategies based on biologicals, there are still no successful therapies to fully stop the chronic inflammatory process.
It is widely assumed that reactive oxygen species are part of the pro-inflammatory process, and are believed to be active players in the destructive processes associated with chronic inflammation. Therefore, the prescription of anti-oxidants has flourished in the past years. However, more evidence is being gathered from human and animal studies, that reactive oxygen species might have a regulatory effect associated with the resolution of inflammation and tolerisation of B and T cells. A significant example comes from patients with chronic granulomatous disease, which have mutations in the proteins of the NADPH-oxidase complex, which impair the production of reactive oxygen species. These patients and family members have more tendency to develop autoimmune conditions. Also, a recent model of chronic arthritis has been developed in mice and rats with defects in the production of reactive oxygen species due to a mutation in the Ncf1 gene of the NADPH-oxidase complex.
Using a combination of human samples from patients with chronic inflammatory diseases and animal models of chronic inflammation, the present proposal aims at exploring the role of the NADPH-oxidase complex and the production of reactive oxygen species in the context of chronic inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences health sciences inflammatory diseases
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics mutation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-ERG-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3004 517 Coimbra
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.