Objective
Reward processing plays a fundamental role in motivation, learning and cognition. Using fMRI in humans, we recently identified the neural structures involved when anticipating uncertain rewards. Cognitive impairments and dysfunction of the dopaminergic system are observed in healthy aging and in several neurological and psychiatric disorders. Moreover, damage from stroke and neurodegeneration in dementia may be retarded by estrogen and estrogens may prevent the deleterious effects of aging on cognition when administered soon after the cessation of ovarian function. However little is known about the effects of ageing and hormone replacement therapy (HRT) on the reward system and dopamine synthesis. The goals of this research program are to investigate the role of ageing in men and women and the effect of age-related hormonal decline in post-menopausal women with and without hormone replacement therapy on activation of the reward system and on dopaminergic. Using both fMRI and fDOPA PET, we shall investigate: 1) the activation of the reward system with fMRI in our monetary reward task; 2) dopamine synthesis in the midbrain and the striatum using F-DOPA PET; 3) the relationships between activation of the reward system and the levels of midbrain/striatum dopamine synthesis by combining fMRI and F-DOPA PET results in the same individuals; 4) the effect of HRT on the reward system and the dopaminergic function in post-menopausal women. Our findings should clarify the relationships between activation of the reward system, dopamine synthesis and the effect of ageing and HRT.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine psychiatry
- medical and health sciences basic medicine neurology dementia
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
D02 CX56 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.