Objective
The proper function of neurotransmitters receptors is highly dependent on their precise subcellular localization in neurons. The molecular and cellular mechanisms that govern the synaptic localization of glutamate receptors both depend on the molecular structure of receptors and on interactions with cytoplasmic and extracellular proteins. These mechanisms have been widely studied using a variety of techniques applied to nonneuronal cells and to dissociated neurons in cultures. In contrast, our aim is to approach this question in an experimental situation which approximates polarized trafficking of receptors in an in vivo situation. Excitatory synaptic transmission in the mammalian brain is primarily mediated by ionotropic glutamate receptors (iGluRs) which fall into three classes: AMPA, NMDA and KARs. These ligand gated ion channels share common architecture, but display divergent functions. Kainate receptors have recently appeared to play an important role in the regulation of the activity of synaptic networks. Kainate receptors are involved in synaptic integration, in synaptic plasticity, in the regulation of neurotransmitter release and in the control of neuronal excitability. These functions require the proper subcellular localization of kainate receptors in specific functional domains of the neuron, necessitating complex cellular and molecular trafficking events. We will study the mechanisms that account for the highly restricted localization of kainate receptors (KARs) in the proximal dendrites of hippocampal CA3 pyramidal cells, at mossy fiber (MF) synapses. For this purpose, we will take advantage of a multidisciplinary integrated approach combining molecular and cellular tools (transgenic mice, organotypic cultures, biolistic transfection) with electrophysiological and imaging techniques.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology materials engineering fibers
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
33076 BORDEAUX CEDEX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.