Objective
Cardiovascular diseases remain the number one cause of death in the western world. Human embryonic stem cells (hESCs) represent a promising source of cells for the treatment of cardiovascular diseases because of their unlimited cell propagation and ability to give rise to different cell types, including cardiomyocytes, endothelial and smooth muscle cells. Cardiomyocytes isolated from hESCs have been shown to form new myocardium after infarct; however, the functional recovery of the myocardium was low and the functional coupling was inexistent since the cardiomyocytes were observed within the scar and not in direct contact with host cardiomyocytes (Laflamme et al., Nat Biotechnol 2007). So far, no studies have reported the benefits of prevascularizing cardiomyocyte cell constructs to enhance in vivo cell viability, grafting and functional coupling. Additionally, we anticipate that the transplantation of these cells using an injectable bioactive gel will enhance cell retention and viability at the injection site. This projects aims at evaluating the neovascularization and myocardium functional recovery after transplanting hESC-derived cardiomyocytes and vascular cells into a myocardial infarction animal model. Recently, we isolated endothelial and smooth muscle cells from hESCs that form microvessels when injected subcutaneously in nude mice and thus might be an important cell source for the vascularization of the myocardium. In addition, this projects aims at developing a bioactive injectable gel to function as a temporary three-dimensional scaffold and a protocol to monitor non-invasively in vivo cell grafting.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3004 517 Coimbra
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.