Objective
Antibody genes in B lymphocytes are assembled from multiple rearranging gene segments, enabling the immune system to protect us from a huge diversity of pathogens. Each B lymphocyte expresses only one antibody specificity on the cell surface (monospecificity), even though there is more than one allele for each antibody chain, a phenomenon termed allelic exclusion. Allelic exclusion requires asynchronous rearrangement of antibody genes combined with feedback inhibition to prevent the assembly of more than one productive allele. This proposal aims to analyze how epigenetic genome modifications influence the asynchronous rearrangements of antibody genes by defining and then altering the precise distribution of histone modifications. Further, to determine the significance of monospecificity to B lymphocyte development and function, this proposal aims to establish a novel gene-targeted mouse that expresses a diverse, but allelically included antibody repertoire. This will provide new insights as to how the immune system reacts specifically against foreign pathogens while maintaining self-tolerance. Hence, this proposal will elucidate the mechanism and importance of allelic exclusion of antibody genes in the immune system. The project will be conducted through a collaboration between the University of Erlangen-Nürnberg, Germany and the University of California, Berkeley, USA. The outcome of this proposal will improve our predictive knowledge of various human diseases including infections, cancer and autoimmune diseases, and thus support sustainable healthcare in the EU.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IOF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91058 ERLANGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.