Objective
The general framework of the project NUCARCHIV is to use the recent development of nano-biotechnology to manipulate and image sophisticated in vitro reconstituted protein-nucleic acids complexes. Our goal is to bring several important advances in our understanding of the inner nucleoprotein structure (the nucleocapsid) of the human immunodeficiency virus (HIV), the causative agent of AIDS. The nucleocapsid complex plays essential roles during HIV assembly and early infection, and its modifications severely impede viral replication. The highly conserved nucleocapsid protein p7NC, the main actor of this complex, is considered as a prime target for developing new compounds with antiviral properties. Studies of nucleocapsid self-assembly, architecture and behavior in the host's cytoplasm are essential prerequisites for a complete description of HIV infection, and for the development of new anti-AIDS chemotherapies or vaccine. We will study by dynamic molecular imaging using atomic force microscopy single nucleoprotein complexes assembled from their purified partners (protein and nucleic acids templates). We will probe how these complexes are topologically modulated by the presence of viral enzymatic activities. Our goal is to provide a movie in real time showing the molecular dynamics of these complexes from virus maturation up to the late steps of early infection. We also propose to study the effect of a new molecule specifically designed to irreversibly inhibit HIV nucleocasid, with a potent application in AIDS prevention as component of next-generation of microbicids.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences microbiology virology
- natural sciences physical sciences optics microscopy
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08036 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.