Objective
Protein kinases mediate most of the signal transduction events in cells by phosphorylation of specific substrates – modifying their activity, cellular location, and/or association with other proteins. The extremely critical role of kinases for critical cellular decisions came evident when an unexpectedly large number of kinases (120/518) were found to be mutationally activated activated or their expression increased due to gene-amplification or translocation in many types of human cancer, suggesting that either a large number of kinase-pathways can contribute to cancer, or that many kinases can regulate the same pathways when activated unphysiologically. These observations point towards a model where cancer can be caused by combinations of multiple different alterations within the cellular systems that control cell and tissue growth, and cancer can thus be clearly described as a complex and multifactorial disease. To date, cancer causing mechanism have been primarily studied using the methods of cell biology, biochemistry and/or genetics, methods which typically reduce complex cellular responses into (often linear) sequences of signaling events. While these efforts have accumulated enormous amounts of detailed information, the heterogeneity of the experimental approaches makes integration of this information into a comprehensive quantitative model a daunting if not impossible task. The critical information about the connectivity of concurrently active signaling pathways, their dynamics and the emergence of physiological responses from molecular events has remained elusive. The main goal of this proposed project is to use systems biology methods to characterize and decipher the cancer linked kinase signalling networks at a molecular and quantitative level to provide the basis for predictive mathematical models for cancer onset. This knowledge of wiring diagram of cancer related kinases will be fundamental in developing therapeutic strategies for cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zurich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.