Objective
Lung cancer is the most frequent cause of tumor-related death in Europe with Non-Small Cell Lung Cancer (NSCLC) representing 75% of all lung tumors. Its molecular pathogenesis is incompletely understood and specifically the role of functional RNAs in this deadly disease remains to be uncovered. Shifting a paradigm, RNA is now recognized not only as a mediator in protein synthesis, but as important functional molecule in the cell. The microRNA family contributes to lung cancer development, but also other classes of non-coding RNA (ncRNA) are linked to this disease. However, their precise functions in pathological as well as physiological processes remain unknown. Previously, we discovered a ncRNA that correlates with metastasis formation in NSCLC termed MALAT-1.
This project aims to characterize the cellular impact, molecular function and prognostic significance of MALAT-1 and the imprinted ncRNA H19 in lung cancer. First, experiments in cell lines with altered ncRNA abundance will unravel their impact on cellular phenotypes like proliferation or migration. Second, identification of interacting proteins of the ncRNAs will elucidate the molecular networks in which these RNAs function and further experiments will analyze their molecular function. Lastly, characterization of the expression and localization of the ncRNAs will determine their potential use as tumor markers for diagnosis or prognosis in tumor samples as well as blood-derived circulating tumor cells.
In summary, this project will shed light on important molecular and cellular functions of ncRNAs in cancer and elucidate their potential as disease markers. In parallel, it allows us to broaden our research focus which would be impossible without this funding and delve into one of the most fascinating fields in RNA biology as well as establish lasting collaborations with outstanding laboratories in the USA and facilitate the integration into the research community in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology lung cancer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.