Objective
Prostate cancer is among the leading tumor types in men in the Western world. The heterogeneity of prostate cancer provides difficulties in tumor classification and decision-making for therapies. The establishment of new biomarkers is essential to develop individual treatments and facilitate tumor categorization. Therapies include hormone deprivation, which initially leads to tumor regression, but is associated with a high rate of recurrence. Both genetic and epigenetic alterations have been found in prostate cancer. Especially overexpression of the Polycomb protein EZH2 has been associated with aggressive tumors and bad prognosis. Additionally, DNA methylation of various genes including tumor suppressors, hormone receptors or cell cycle regulators has been described. Here we aim to investigate epigenetic patterns in human prostate cancer tissues before and after hormone ablation therapy, to evaluate novel biomarkers and to identify novel target genes of epigenetic mechanisms. We intend to monitor changes in epigenetic marks such as DNA methylation and Polycomb protein occupancy in prostate cancers before and after hormone deprivation. Furthermore, we aim to test our previous results obtained in prostate cancer cell lines to learn more about the clinical significance of epigenetic mechanisms in prostate cancer. The use of epigenetic drugs, such as DNA methyltransferase inhibitors and histone deacetylase inhibitors has been approved by the US food and drug administration for the treatment of specific hematological malignancies, and clinical trials have shown the beneficial effects for several tumor types. Thus, our study may elucidate novel molecular mechanisms of the disease and provide a rationale for the application of epigenetic drugs to target prostate cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1090 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.