Objective We propose a systems biology study of the specificity of response of the cell-mediated immune system to fungal microorganisms in order to investigate the genetic basis of susceptibility to fungal disease and elucidate molecular mechanisms of drug resistance in fungal pathogens. An integrative approach, combining high-throughput and traditional wet-lab work with computational and bioinformatics methods, will be applied to identify biomarkers of resistance to currently available treatments and to develop novel putative drug target genes and pathways in different fungi. We will use Saccharomyces cerevisiae, a normally non-pathogenic yeast model organism, Candida albicans and Aspergillus fumigatus, two major recognized fungal pathogens as well as other Aspergillus spp. known to be multi-drug resistant and difficult to treat. This project meets the criteria of the call, the strategic objective of which is “to confront the increasing emergence and spread of antimicrobial drug resistant pathogens in Europe” by addressing a well-defined class of infectious disease caused by fungal pathogens, with significant morbidity and mortality in a large segment of the population, and a high economic cost due to resistance. The anticipated results are highly relevant to society in terms of reducing the burden of mortality and suffering in immunosuppressed patients and in terms of reducing medical costs associated with treating opportunistic fungal infections. The potential economic upside for novel broad-spectrum anti-infectives is very large. The worldwide market for antifungals is currently estimated at $4 billion US annually. We tackle the issues of anti-microbial drug resistance head on via a multidisciplinary systems biology study combining bacterial genetics, clinical and pharmacological research in a systems biology approach, integrating traditional wet-lab methods with those of functional genomics, proteomics, metabolomics and bioinformatics. Fields of science social sciencessociologydemographymortalitymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Keywords GWAS antifungal resistance functional genomics immunopharmacology pathway analysis systems biology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.3.1-2 - Impact of specific antibiotic therapies on the prevalence of resistant bacteria in the human host Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator EUROPEAN MOLECULAR BIOLOGY LABORATORY EU contribution € 867 883,00 Address Meyerhofstrasse 1 69117 Heidelberg Germany See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Tom Ratcliffe (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI FIRENZE Italy EU contribution € 336 800,00 Address Piazza san marco 4 50121 Florence See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Administrative Contact Alessandro Mugelli (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 591 716,40 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDADE DE AVEIRO Portugal EU contribution € 291 457,00 Address Campus universitário de santiago 3810-193 Aveiro See on map Region Continente Centro (PT) Região de Aveiro Activity type Higher or Secondary Education Establishments Administrative Contact Manuel António Da Silva Santos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 299 842,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Béatrice Saint-Cricq (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALERGENETICA SL Spain EU contribution € 486 000,00 Address "calderon de la barca 5, 5, #27" 38005 Santa cruz de tenerife See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Brian Miller (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI PERUGIA Italy EU contribution € 200 000,00 Address Piazza dell universita 1 06123 Perugia See on map Region Centro (IT) Umbria Perugia Activity type Higher or Secondary Education Establishments Administrative Contact Rosario Francesco Donato (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Participation ended France EU contribution No data Address Rue leblanc 25 75015 Paris 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Elizabeth May (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO PARC CIENTIFIC DE BARCELONA Spain EU contribution € 1 217 463,00 Address Baldiri i reixac 4 08028 Barcelona See on map Region Este Cataluña Barcelona Administrative Contact Moises Tarte (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data