Objectif Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of cells, signalling mechanisms and extracellular matrix. Regenerative medicine/tissue engineering technologies are based on this biological triad and involve the successful interaction between three components: the scaffold that holds the cells together to create the tissues physical form, the cells that create the tissue, and the biological signalling mechanisms (such as growth factors or bioreactors) that direct the cells to express the desired tissue phenotype. The research proposed in this project includes specific projects in all three areas. The programme will be centred on the collagen-based biomaterials developed in the applicant s laboratory and will incorporate cutting edge stem cell technologies, growth factor delivery, gene therapy and bioreactor technology which will translate to in vivo tissue repair. This translational research programme will be divided into four specific themes: (i) development of novel osteoinductive and angiogenic smart scaffolds for bone tissue regeneration, (ii) scaffold and stem cell therapies for bone tissue regeneration, (iii) bone tissue engineering using a flow perfusion bioreactor and (iv) in vivo bone repair using engineered bone and smart scaffolds. Champ scientifique engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologyindustrial biotechnologybiomaterials Mots‑clés angiogenesis bioreactor bone collagen gene therapy osteogenesis regenerative medicine scaffolds stem cells tissue engineering Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE8 - ERC Starting Grant - Products and process engineering Appel à propositions ERC-2009-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil ROYAL COLLEGE OF SURGEONS IN IRELAND Contribution de l’UE € 1 999 530,00 Adresse ST STEPHEN'S GREEN 123 2 Dublin Irlande Voir sur la carte Région Ireland Northern and Western Border Type d’activité Higher or Secondary Education Establishments Contact administratif Paola Della Porta (Dr.) Chercheur principal Fergal Joseph O'brien (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ROYAL COLLEGE OF SURGEONS IN IRELAND Irlande Contribution de l’UE € 1 999 530,00 Adresse ST STEPHEN'S GREEN 123 2 Dublin Voir sur la carte Région Ireland Northern and Western Border Type d’activité Higher or Secondary Education Establishments Contact administratif Paola Della Porta (Dr.) Chercheur principal Fergal Joseph O'brien (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée