Obiettivo Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of cells, signalling mechanisms and extracellular matrix. Regenerative medicine/tissue engineering technologies are based on this biological triad and involve the successful interaction between three components: the scaffold that holds the cells together to create the tissues physical form, the cells that create the tissue, and the biological signalling mechanisms (such as growth factors or bioreactors) that direct the cells to express the desired tissue phenotype. The research proposed in this project includes specific projects in all three areas. The programme will be centred on the collagen-based biomaterials developed in the applicant s laboratory and will incorporate cutting edge stem cell technologies, growth factor delivery, gene therapy and bioreactor technology which will translate to in vivo tissue repair. This translational research programme will be divided into four specific themes: (i) development of novel osteoinductive and angiogenic smart scaffolds for bone tissue regeneration, (ii) scaffold and stem cell therapies for bone tissue regeneration, (iii) bone tissue engineering using a flow perfusion bioreactor and (iv) in vivo bone repair using engineered bone and smart scaffolds. Campo scientifico engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologyindustrial biotechnologybiomaterials Parole chiave angiogenesis bioreactor bone collagen gene therapy osteogenesis regenerative medicine scaffolds stem cells tissue engineering Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-PE8 - ERC Starting Grant - Products and process engineering Invito a presentare proposte ERC-2009-StG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante ROYAL COLLEGE OF SURGEONS IN IRELAND Contributo UE € 1 999 530,00 Indirizzo ST STEPHEN'S GREEN 123 2 Dublin Irlanda Mostra sulla mappa Regione Ireland Northern and Western Border Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Paola Della Porta (Dr.) Ricercatore principale Fergal Joseph O'brien (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ROYAL COLLEGE OF SURGEONS IN IRELAND Irlanda Contributo UE € 1 999 530,00 Indirizzo ST STEPHEN'S GREEN 123 2 Dublin Mostra sulla mappa Regione Ireland Northern and Western Border Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Paola Della Porta (Dr.) Ricercatore principale Fergal Joseph O'brien (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
