Objective
Neisseria meningitidis (Nm) is a leading cause of bacterial meningitis and septicemia worldwide with a high case-fatality rate. Although penicillin remains the drug of choice in the treatment of IMD, an increasing number of meningococci with reduced susceptibility to penicillin have been emerging worldwide. Reduces susceptibility or resistance to penicillin in meningococci is connected to alterations in penicillin binding protein 2, PBP2. PBPs are involved in the late stages of peptidoglycan (PG) biosynthesis and therefore PBPs alterations might result in PG modifications and hence affect PG-dependent signalling. Until recently it was thought that N. meningitidis strains own only three PBPs, PBP1, PBP2 and PBP3. However, genomic analysis of the complete sequence of meningococcal strains revealed the presence of two other putative genes encoding PBP4 and PBP5 which can possess D,D-carboxypeptidase and endopeptidase activity. And indeed the results obtained during the previous Marie Curie IEF from the PG structure study as well as from animal model provide the first indication that putative PBP4 and PBP5 are functional in N. meningitidis, play a role in the PG synthesis and influence the virulence of meningococcal isolates. It has been proposed for some bacteria that different enzymes involved in PG biosynthesis might act in concert or may form more active dimmer forms in vivo. Therefore the aim of this project is to study the interactions between penicillin binding proteins of Neisseria meningitidis and their functional organisation. The project will use a multidisciplinary approach applying bacteriological, molecular and biochemical methods as well as electron microscopy. The research should give a possibility to determine interactions between different PBPs of meningococci and to elucidate a role of different parts/domains of PBPs through the assessment of their influence on structural modification of N. meningitidis PG.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-ERG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00 725 Warszawa
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.