Objective
Molecular recognition plays a fundamental role in nearly all chemical and biological processes. The objective of this research project is to develop new methodology for studying and utilizing the noncovalent recognition between two molecular entities, focussing on biomolecular receptors and catalysts. A dynamic covalent capture strategy is proposed, characterized by the following strongholds. The target itself self-selects the best component out of a combinatorial library. The approach has a very high sensitivity, because molecular recognition occurs intramolecularly, and is very flexible, which allows for an easy implementation in very diverse research areas simply by changing the target. The dynamic covalent capture strategy is strongly embedded in the fields of supramolecular chemistry and (physical) organic chemistry. Nonetheless, the different work programmes strongly rely on the input from other areas, such as combinatorial chemistry, bioorganic chemistry, catalysis and computational chemistry, which renders the project highly interdisciplinary. Identified targets are new synthetic catalysts for the selective cleavage of biologically relevant compounds (D-Ala-D-Lac, cocaine and acetylcholine, and in a later stage peptides and DNA/RNA). Applicative work programmes are dedicated to the dynamic imprinting of monolayers on nanoparticles for multivalent recognition and cleavage of biologically relevant targets in vivo and to the development of new screening methodology for measuring chemical equilibria and, specifically, for the discovery of new HIV-1 fusion inhibitors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences organic chemistry
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences catalysis
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
35122 PADOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.