Objective The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans. We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo. Pten induced cellular senescence (PICS) occurs at early time points after Pten inactivation even in absence of cellular proliferation and DNA Damage. I will discuss the mechanism that trigger PICS in cancer, hailing the potential therapeutic implication of p53 stabilizing drugs and Pten inhibitors. Importantly, I will discuss how the oncogenic stress induced by complete loss of Pten can still triggers senescence in cells with low proliferative potential, such as cancer stem cells. I propose to apply this model to the treatment of pediatric brain tumors. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants" Call for proposal FP7-PEOPLE-2007-4-3-IRG See other projects for this call Funding Scheme MC-IRG - International Re-integration Grants (IRG) Coordinator Ente Ospedaliero Cantonale EU contribution € 100 000,00 Address Vialle Officina 3 CH-6500 Bellinzona Switzerland See on map Region Schweiz/Suisse/Svizzera Ticino Ticino Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Gianfranco Bozzini (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all PROVINCIA RELIGIOSA DI SAN PIETRO DELL'ORDINE OSPEDALIERO DI SAN GIOVANNI DI DIO, DETTO FATEBENEFRATELLI Participation ended Italy EU contribution € 100 000,00 Address Via Cassia 600 00189 ROMA See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Vittorio Cirucci (Dr.) Links Contact the organisation Opens in new window Total cost No data
