Objective
Replication of positive-strand RNA viruses is a complicated process that involves the virus genome, virus proteins and host factors. In this system, an active replication complex is formed and the central role is played by the viral RNA dependent RNA polymerase. Pepino mosaic virus (PepMV) is a mechanically-transmitted plant virus member of the genus Potexvirus, currently under quarantine in Europe and with great potential of causing serious economical losses to tomato industry. This work extends a recently established bilateral (Greece-Spain) and takes advantage of great expertise of an incoming scientist from Egypt to: 1) purify PepMV membrane-bound replication complexes from infected tomato plants and try to convert them into a soluble, template dependent system for the analysis of viral RNA synthesis, and 2) identify tomato proteins that specifically bind PepMV-encoded proteins and PepMV RNAs (5'- and 3'-untranslated regions). We attempt to establish a model on PepMV to generate valuable data on virus replication with an emphasis on host protein factors. The analysis of viral replication complex components and the identification of the host factors and their role in viral replication constitute two key issues in virology and understanding the mechanisms of viral replication is essential for devising strategies to combat virus-induced diseases. We also intend to extend a research link between three Mediterranean laboratories (Greece, Spain and Egypt) with the view of growing broader and multidisciplinary in the future (e.g. private sector, governmental services, research groups, human capital) given the expansion of the virus and a recent agreement for the establishment of a Euro-Mediterranean Free Trade Area by the year 2010. The proposal capitalizes on the quality of the researcher, the importance of the system chosen in the field of virology and the return potential for the incoming scientist, the host Institute and the expansion of the cooperation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases RNA viruses
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
73 100 CHANIA
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.